Cancer cells can treat tumors.
New check out suggests that many cancer cells are equipped with a gracious of suicide pill: a protein on their surfaces that gives them the genius to turn an ?eat me? noteworthy to immune cells. The doubt now, the researchers say, is to upon out how to coax cancer cells into emitting the conspicuous rather than a dangerous ?don?t eat me? signal niconot in honolulu. A think over published online Dec 22 2010 in Science Translational Medicine reports that the cells propel out the enticing ?eat me? singular by displaying the protein calreticulin.
But another molecule, called CD47, allows most cancer cells to steer clear of holocaust by sending the antagonistic signal: ?Don?t break bread me?. In earlier research, Stanford University School of Medicine scientists found that an antibody that blocks CD47 -- turning off the outstanding -- could mitigate dissent cancer, but mysteries remained. ?Many regular cells in the body have CD47, and yet those cells are not upset by the anti-CD47 antibody,? Mark Chao, a Stanford bachelor disciple and the study?s lead author, said in a university rumour release.
And ?At that time, we knew that anti-CD47 antibody healing selectively killed only cancer cells without being toxic to most run-of-the-mill cells, although we didn?t separate why?. Now, the uncharted research has shown that calreticulin exists in a miscellany of cancers, including some types of leukemia, non-Hodgkin?s lymphoma and bladder, perceptiveness and ovarian cancers.
So ?This examine demonstrates that the saneness that blocking the CD47 ?don?t eat me? nod works to kill cancer is that leukemias, lymphomas and many packed tumors also display a calreticulin ?eat me? signal,? Dr Irving Weissman, commandant of the Stanford Institute for Stem Cell Biology and Regenerative Medicine and a co-principal investigator of the study, said in the release. ?The inquiry also shows that most general room populations don?t spectacle calreticulin and are, therefore, not depleted when we show them to a blocking anti-CD47 antibody?.
The next track is to realize how calreticulin works. ?We want to be versed how it contributes to the disease process and what is phenomenon in the cell that causes the protein to move to the stall surface,? Dr Ravindra Majeti, an aide-de-camp professor of hematology and study co-principal investigator, said in the release saudi arabia men tumblr. ?Any of these mechanisms put forward future new ways to treat the infirmity by interfering with those processes,? Majeti said.
Source: http://emiliahdelia.unblog.fr/2012/02/01/cancer-cells-can-treat-tumors/
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